Keith St. Lawrence

Journal Articles

  1. Milej, D., Abdalmalak, A., Diop, M., Liebert, A., & K. St. Lawrence. Time-resolved subtraction method for measuring optical properties of homogeneous turbid media. Appl Opt 55(7): 1507-1513 (2016) - [Published]
  2. Bakhsheshi, M.F., Diop, M., Morrison, L.B., St. Lawrence, K., & T.-Y. Lee. Coupling of cerebral blood flow and oxygen consumption during hypothermia in newborn piglets as measured by time-resolved near-infrared spectroscopy: a pilot study. 2(3): 035006 (2015) - [Published | PMID: 26835481]
  3. Diop, M., Kishimoto, J., Toronov, V., Lee, D., & K. St. Lawrence. Development of a combined broadband near-infrared and diffusion correlation system for monitoring cerebral blood flow and oxidative metabolism in preterm infants. Biomed Opt Express 6(10): 3907-3918 (2015) - [Published | PMID: 26504641]
  4. Verdecchia, K., Diop, M., Morrison, L.B., Lee, T.-Y., & K. St. Lawrence. Assessment of the best flow model to characterize diffuse correlation spectroscopy data acquired directly on the brain. Biomed Opt Express 6(11): 4288-4301 (2015) - [Published | PMID: 26600995]
  5. Anazodo, U., Thiessen, J.D., Ssali, T., Mandel, J., Gunther, M., Butler, J., Pavlosky, W.F., Prato, F.S., Thompson, R.T., & K. St. Lawrence. Feasibility of simultaneous whole-brain imaging on an integrated PET-MRI system using an enhanced 2-point Dixon attenuation correction method. Front Neurosci 8: 1-11 (2015) - [Published]
  6. Diop, M., Wright E., Toronov, V., Lee, T.-Y., & K. St. Lawrence. Improved light collection and wavelet de-noising enable quantification of cerebral blood flow and oxygen metabolism by a low-cost, off-the-shelf spectrometer. J Biomed Opt 19(5): 057007 (2014) - [Published | PMID: 24821577]
  7. Najiminaini, M., Kaminska, B., St. Lawrence, K., & J.J.L. Carson. Bolus tracking with nanofilter-based multispectral videography for capturing microvasculature hemodynamics. Scientific Reports 4(4737): 1-9 (2014) - [Published]
  8. Bakhsheshi, M.F., Diop, M., St. Lawrence, K., & T.-Y. Lee. Monitoring brain temperature by time-resolved near-infrared spectroscopy: A pilot study. J Biomed Opt 19(5): 057005 (2014) - [Published | PMID: 24817622]
  9. Tichauer, K., Diop, M., Elliott, J.T., Samkoe, K.S., Hasan, T., St. Lawrence, K., & B.W. Pogue. Accounting for pharmacokinetic differences in dual-tracer receptor density imaging. Phys Med Biol 59(10): 2341-2351 (2014) - [Published | PMID: 24743262]
  10. Elliott, J.T., Diop, M., Morrison, L.B., d'Esterre, C.D., Lee, T.-Y., & K. St. Lawrence. Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method. NeuroImage 94: 303-311 (2014) - [Published | PMID: 24650601]
  11. Zuo Z, Wang, R., Zhuo, Y., Xue, R., St. Lawrence, K., & D.J. Wang. Turbo-FLASH based arterial spin labeled perfusion MRI at 7 T. PLOS ONE 8(6): (2013) - [Published | PMID: 23818950]
  12. Kishimoto, J., deRibaupierre, S., Lee, D.S., St. Lawrence, K., & A. Fenster. 3D ultrasound system to investigate intraventricular hemorrhage in preterm neonates. Phys Med Biol 58(21): 7513-7526 (2013) - [Published | PMID: 24099882]
  13. Anazodo, U., Shoemaker, K., Suskin, N., & K. St. Lawrence. An investigation of changes in regional grey matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation. NeuroImage 3: 388-395 (2013) - [Published | PMID: 24273722]
  14. Diop, M., & K. St. Lawrence. Improving the depth sensitivity of time-resolved measurements by extracting the distribution of times-of-flight. Biomed Opt Express 4(3): 447-459 (2013) - [Published | PMID: 23504445]
  15. Verdecchia, K., Diop, M., Lee, T.-Y., & K. St. Lawrence. Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy. J Biomed Opt 18(12): 027007-1-027007-9 (2013) - [Published | PMID: 23389684]
  16. Clarke, C., & K. St. Lawrence. Functional imaging for interpretation of pain pathways: current clinical application/relevance and future initiatives. Curr Pain Headache Rep 17(2): 311-1-311-6 (2013) - [Published | PMID: 23315051]
  17. St. Lawrence, K., Verdecchia, K., Elliott, J.T., Tichauer, K., Diop, M., Hoffman, L., & T.-Y. Lee. Kinetic model optimization for characterizing tumour physiology by dynamic contrast-enhanced near-infrared spectroscopy. Phys Med Biol 58(5): 1591-1604 (2013) - [Published | PMID: 23417099]
  18. Arora, R., Ridha, M., Lee, D.S., Elliott, J.T., Rosenberg, H., Diop, M., Lee, T.-Y., & K. St. Lawrence. Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus. Pediatr Res 73(6): 713-718 (2013) - [Published | PMID: 23493169]
  19. Elliott, J.T., Milej, D., Gerega, A., Weigl, W., Diop, M., Morrison, L.B., Lee, T.-Y., Liebert, A., & K. St. Lawrence. Variance of time-of-flight distribution is sensitive to cerebral flow dynamics of indocyanine green as confirmed by comparing scalp and brain measurements in adult pigs.. Biomed Opt Express 4(2): 206-218 (2013) - [Published | PMID: 23413183]
  20. Yeganeh, H.Z., Toronov, V., Elliott, J.T., Diop, M., Lee, T.-Y., & K. St. Lawrence. Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations. Biomed Opt Express 3(11): 2761-2770 (2012) - [Published | PMID: 23162714]
  21. Diop, M., & K. St. Lawrence. Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements. Optics Letters 37(12): 2358-2360 (2012) - [Published | PMID: 22739907]
  22. Diop, M., Verdecchia, K., Lee, T.-Y., & K. St. Lawrence. Erratum: Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements: errata. Biomed Opt Express 3(6): 1476-1477 (2012) - [Published | PMID: 22741092]
  23. St. Lawrence, K., Owen, D., & D.J. Wang. A two-stage approach for measuring vascular water exchange and arterial transit time by diffusion-weighted perfusion MRI. Magn Reson Med 67(5): 1275-1284 (2012) - [Published | PMID: 21858870]
  24. Owen, D., Clarke, C., Bureau, Y., Ganapathy, S., Prato, F.S., & K. St. Lawrence. Measuring the neural response to continuous intramuscular infusion of hypertonic saline by perfusion MRI. J Magn Reson Imaging 35(3): 669-677 (2012) - [Published | PMID: 21953816]
  25. Elliott, J.T., Diop, M., Lee, T.-Y., & K. St. Lawrence. Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters. Optics Letters 37(13): 2571-2573 (2012) - [Published | PMID: 22743458]
  26. Elliott, J.T., Wright E., Tichauer, K., Diop, M., Morrison, L.B., Pogue, B.W., Lee, T.-Y., & K. St. Lawrence. Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements.. Phys Med Biol 57(24): 8285-8295 (2012) - [Published | PMID: 23190567]
  27. Tichauer, K., Migueis, M., Leblond, F., Elliott, J.T., Diop, M., St. Lawrence, K., & T.-Y. Lee. Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data. Appl Opt 50(21): 3962-3972 (2011) - [Published | PMID: 21772380]
  28. Winter, J., St. Lawrence, K., & H.L. Margaret Cheng. Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J Magn Reson Imaging 34(3): 608-615 (2011) - [Published | PMID: 21761490]
  29. Diop, M., Verdecchia, K., Lee, T.-Y., & K. St. Lawrence. Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements. Biomed Opt Express 2(7): 2068-2082 (2011) - [Published | PMID: 21750781]
  30. Cooper, J.A., Tichauer, K., Boulton, M., Elliott, J.T., Diop, M., Arango, M., Lee, T.-Y., & K. St. Lawrence. Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusion. J Appl Physiol 110(6): 1691-1698 (2011) - [Published | PMID: 21454747]
  31. Winter, J., Dorner, S., Lukovic, J., Fisher, J.A., St. Lawrence, K., & A. Kassner. Noninvasive MRI measures of microstructural and cerebrovascular changes during normal swine brain development. Pediatr Res 69(5): 418-424 (2011) - [Published | PMID: 21258264]
  32. Pucci, O., Toronov, V., & K. St. Lawrence. Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy. Appl Opt 49(32): 6324-6332 (2010) - [Published | PMID: 21068864]
  33. Winter, J., Fierstra, J., Dorner, S., Fisher, J.A., St. Lawrence, K., & A. Kassner. Feasibility and precision of cerebral blood flow and cerebrovascular reactivity MRI measurements using a computer-controlled gas delivery system in an anesthetised juvenile animal model. J Magn Reson Imaging 32(5): 1068-1075 (2010) - [Published | PMID: 21031510]
  34. Diop, M., Tichauer, K., Elliott, J.T., Migueis, M., Lee, T.-Y., & K. St. Lawrence. Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets. J Biomed Opt 15(5): 057004 (2010) - [Published | PMID: 21054120]
  35. Tichauer, K., Elliott, J.T., Hadway, J., Lee, D.S., Lee, T.-Y., & K. St. Lawrence. Using near-infrared spectroscopy to measure cerebral metabolic rate of oxygen under multiple levels of arterial oxygenation in piglets. J Appl Physiol 109(3): 878-885 (2010) - [Published | PMID: 20616228]
  36. Elliott, J.T., Diop, M., Tichauer, K., Lee, T.-Y., & K. St. Lawrence. Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy. J Biomed Opt 15(3): 037014 (2010) - [Published | PMID: 20615043]
  37. Wu, W.C., St. Lawrence, K., Licht, D.J., & D.J. Wang. Quantification issues in arterial spin labeling perfusion magnetic resonance imaging. Top Magn Reson Imaging 21(2): 65-73 (2010) - [Published | PMID: 21613872]
  38. Owen, D., Clarke, C., Ganapathy, S., Prato, F.S., & K. St. Lawrence. Using Perfusion MRI to measure the dynamic changes in neural activation associated with tonic muscular pain. Pain 148(3): 375-386 (2010) - [Published | PMID: 19914778]
  39. Diop, M., Elliott, J.T., Tichauer, K., Lee, T.-Y., & K. St. Lawrence. Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia ischemia. Rev Sci Instrum 80(5): 054302 (2009) - [Published | PMID: 19485521]
  40. Tichauer, K., Elliott, J.T., Hadway, J., Lee, T.-Y., & K. St. Lawrence. Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia ischemia. J Appl Physiol 106(5): 1506-1512 (2009) - [Published | PMID: 19299571]
  41. Winter, J., Tichauer, K., Gelman, N., Thompson, R.T., Lee, T.-Y., & K. St. Lawrence. Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: A combined near-infrared and magnetic resonance spectroscopy study. Pediatr Res 65(2): 181-187 (2009) - [Published | PMID: 18852691]
  42. Tichauer, K., Wong, D.Y., Hadway, J., Rylett, R.J., Lee, T.-Y., & K. St. Lawrence. Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen. Pediatr Res 65(3): 301-306 (2009) - [Published | PMID: 19033882]
  43. Owen, D., Bureau, Y., Thomas, A.W., Prato, F.S., & K. St. Lawrence. Quantification of pain-induced changes in cerebral blood flow by perfusion MRI. Pain 136(1-2): 85-96 (2008) - [Published | PMID: 17716820]
  44. Koziak, A., Winter, J., Lee, T.-Y., Thompson, R.T., & K. St. Lawrence. Validation study of a pulsed arterial spin labeling technique by comparison to perfusion computed tomography. Magn Reson Imaging 26(4): 543-553 (2008) - [Published | PMID: 18063336]
  45. Wang, J., Fernandez-Seara, M.A., Wang, S., & K. St. Lawrence. When perfusion meets diffusion: in vivo measurement of water permeability in human brain. J Cereb Blood Flow Metab 27(4): 839-849 (2007) - [Published | PMID: 16969383]
  46. Tichauer, K., Hadway, J., Lee, T.-Y., & K. St. Lawrence. Measurement of cerebral oxidative metabolism with near-infrared spectroscopy: a validation study. J Cereb Blood Flow Metab 26(5): 722-730 (2006) - [Published | PMID: 16192991]
  47. Tichauer, K., Brown, D.W., Hadway, J., Lee, T.-Y., & K. St. Lawrence. Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets. J Appl Physiol 100(3): 850-857 (2006) - [Published | PMID: 16293704]
  48. St. Lawrence, K., & J. Wang. Effects of the apparent transverse relaxation time on cerebral blood flow measurements obtained by arterial spin labeling. Magn Reson Med 53(2): 425-433 (2005) - [Published | PMID: 15678532]
  49. St. Lawrence, K., Frank, J.A., Bandettini, P.A., & F.Q. Ye. Noise reduction in multi-slice arterial spin tagging imaging. Magn Reson Med 53(3): 735-738 (2005) - [Published | PMID: 15723412]
  50. St. Lawrence, K., Ye, F.Q., Lewis, B.K., Frank, J.A., & A.C. McLaughlin. Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation. Magn Reson Med 50(1): 99-106 (2003) - [Published | PMID: 12815684]
  51. Barbier, E.L., St. Lawrence, K., Grillon, E. , Koretsky, A.P., & M. Decorps. A model of blood-brain barrier permeability to water: accounting for blood inflow and longitudinal relaxation effects. Magn Reson Med 47(6): 1100-1109 (2002) - [Published | PMID: 12111956]
  52. St. Lawrence, K., Ye, F.Q., Lewis, B.K., Weinberger, D.R., Frank, J.A., & A.C. McLaughlin. Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans. J Magn Reson Imaging 15(6): 628-635 (2002) - [Published | PMID: 12112512]
  53. St. Lawrence, K., & T.-Y. Lee. An adiabatic approximation to the tissue homogeneity model for water exchange in the brain II. Experimental Validation. J Cereb Blood Flow Metab 18: 1378-1385 (1998) - [Published | PMID: 9850150]
  54. St. Lawrence, K., & T.-Y. Lee. An adiabatic approximation to the tissue homogeneity model for water exchange in the brain I. Theoretical derivation. J Cereb Blood Flow Metab 18: 1365-1377 (1998) - [Published | PMID: 9850149]
  55. St. Lawrence, K., Lee, T.-Y., & M. Henkelman. Spatial localization combining projection presaturation with a two-dimensional excitation pulse. Magn Reson Imaging 40: 944-947 (1998) - [Published | PMID: 9840842]
  56. St. Lawrence, K., Bews, J., Dunscombe, P.B., & T.-Y. Lee. Regional cerebral perfusion measurements: A comparative study of xenon enhanced CT and C15O2 buildup using dynamic PET. Phys Med Biol 37: 379-390 (1992) - [Published]

Proceedings Articles

  1. Tavakolian, P., Todd, R., Kosik, I., Chamson-Reig, A., Vasefi, F., St. Lawrence, K., & J.J.L. Carson. Development of a neonatal skull phantom for photoacoustic imaging. Proc. SPIE 8581: 858146-1-858146-6 (2013) - [Published]
  2. Tavakolian, P., Kosik, I., Chamson-Reig, A., St. Lawrence, K., & J.J.L. Carson. Potential for photoacoustic imaging of the neonatal brain. Proc. SPIE 8581: 858147-1-858147-6 (2013) - [Published]
  3. Verdecchia, K., Elliott, J.T., Diop, M., Hoffman, L., Lee, T.-Y., & K. St. Lawrence. Assessing tumor physiology by dynamic contrast-enhanced near-infrared spectroscopy. Proc. SPIE 8578: (2013) - [Published]
  4. Toronov, V., Elliott, J.T., Lee, T.-Y., & K. St. Lawrence. Depth-resolved quantitative measurement of cerebral blood flow using broad-band near infrared spectroscopy and a two-layer head model. Proc. SPIE 8088: 80881J (2011) - [Published]
  5. Elliott, J.T., Tichauer, K., Diop, M., & K. St. Lawrence. Fast Monte Carlo fitting of two-layered tissue structures for short source-detector distances. Proc SPIE 7896: 789611 (2011) - [Published]
  6. Elliott, J.T., Diop, M., Tichauer, K., Lee, T.-Y., & K. St. Lawrence. Monte Carlo based modeling of indocyanine green bolus tracking in the adult human head. Proc SPIE 7896: 78960E (2011) - [Published]
  7. Diop, M., Lee, T.-Y., & K. St. Lawrence. Continuous monitoring of absolute cerebral blood flow by combining diffuse correlation spectroscopy and time-resolved near-infrared technology. Proc SPIE 7896: 78960F (2011) - [Published]
  8. Diop, M., Tichauer, K., Elliott, J.T., Migueis, M., Lee, T.-Y., & K. St. Lawrence. Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow. Proc SPIE 7555: 75550Z (2010) - [Published]

Book Chapters

  1. St. Lawrence, K., Owen, D., & F.S. Prato. Advanced signal processing, theory and implementation for sonar, radar and non-invasive medical diagnostic systems. Stergios Stergiopoulos ed., CRC Press, (2009)

Reports

  1. Théberge, J., Lanius, R.A., St. Lawrence, K., Prato, F.S., Thompson, R.T., Thomas, A.W., & R.Z. Stodilka. Investigation of the Effects of Closed-Head Injury using Neurophysiological, Neuroimaging and Neurocognitive Assessment – *Phase 3, Task 1*. Lawson Health Research Institute (2008)
  2. Théberge, J., St. Lawrence, K., Thompson, R.T., Thomas, A.W., & R.Z. Stodilka. Investigation of the Effects of Closed-Head Injury using Neurophysiological, Neuroimaging and Neurocognitive Assessment – *Phase 3, Task 2*. Lawson Health Research Institute (2008)
  3. Stodilka, R.Z., Carson, J.J.L., Gow, J., St. Lawrence, K., Lebrun, C.M., Legros, A., & A.W. Thomas. Diagnostic Assessment of Cerebral Impairment in Canadian Forces (CF) Operations – *Phase I , Milestone 2* Final Report. Lawson Health Research Institute (2007)

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